Frozen Eggs Beat IVF For Women Delaying Pregnancy

Frozen Eggs Beat IVF For Women Delaying Pregnancy



For women starting families later in life, frozen eggs are a more effective option than in vitro fertilization, according to new research.

The study found that 70% of women who froze eggs when they were under 38 and thawed at least 20 eggs afterwards had a baby.

The research is based on 15 years of actual frozen egg thawing results and the largest US report of elective fertility preservation results to date.

Posted in Fertility and sterility, the study also revealed that a considerable number of the women studied had more than one child thanks to egg storage. In total, the study reports 211 babies resulting from egg freezing.

In comparison, and using fresh eggs or embryos from women trying to conceive, by age 40 less than 30% of women receiving in vitro fertilization (IVF) become pregnant and less than 20% have given birth to babies as a result. alive, according to statistics gathered by the Centers for Disease Control and Prevention (CDC) from the approximately 500 fertility clinics nationwide.

Freezing and thawing eggs at a later date provides a higher pregnancy success rate than using fresh embryos during assisted reproductive technology, researchers say.

More older women are giving birth

“Our results shed light on the factors that follow successful births with egg freezing, including careful screening of embryos to be thawed and implanted,” says lead author Sarah Druckenmiller Cascante, member of the Division of Endocrinology Reproductive and Infertility, within the Department of Obstetrics and Gynecology at NYU Langone.

“A better understanding of the live birth rate of egg freezing for age-related fertility decline is needed to inform patient decision-making.”

“It is important to note that our study is based on real clinical experience,” adds Cascante, “rather than mathematical modeling with limited data, which is consistent with most of what has been published on birth chances. by egg freezing so far”.

The number of American women having children in old age has increased for three decades, with evidence that the trend will continue. Birth rates declined for women in their 20s and jumped for women in their late 30s and early 40s, according to the US Census Bureau. The average age at first birth has increased from 19 years in 1984 to 30 years in 2021 and is higher in many cities.

Women can be their own egg donor

In the study, 543 patients participated with an average age of 38 at the time of first egg freezing, which is older than the optimal age for egg freezing (35 years or younger). These patients had 800 cycles of egg freezing, 605 egg thawing and 436 embryo transfers between 2005 and 2020.

The survey found that, overall, 39% of women aged 27 to 44, with a majority between 35 and 40 at the time of egg freezing, had at least one child from their frozen eggs, which which is comparable to age-matched IVF results. .

At all ages, women who thawed more than 20 mature eggs had a live birth rate of 58%, which was profound and unexpected because this group included people past their reproductive peak. In fact, 14 patients who froze eggs at the age of 41 to 43 managed to have children from their frozen eggs.

As noted, women under 38 who had thawed 20 or more mature eggs achieved a live birth rate of 70% per patient. Shelf life of frozen eggs did not affect the success rate.

The results also showed that preimplantation genetic screening with frozen and possibly thawed egg embryos resulted in lower miscarriage rates and higher live birth rates per transfer. Such screening also allows single embryo transfers, resulting in singleton pregnancies, which are safer for both mother and child, the researchers say.

“Our results provide realistic expectations for those considering oocyte preservation and demonstrate that egg freezing technology gives women greater reproductive autonomy,” says lead author James A. Grifo, director of the division of endocrinology. Reproductive and Infertility and the Fertility Center.

“Freezing eggs at a young age becomes an option for being your own egg donor at an older age. As younger patients freeze eggs and complete more than one cycle, success rates will be even higher than reported in this study.

Grifo, also a professor in the department of obstetrics and gynecology, warns that the study was limited by the number of patients. Future larger studies are underway to increase the data set that patients can benefit from and model their expected success rates. He adds that additional studies from a variety of geographic locations and types of centers are also needed.

The Carolyn and Malcom Wiener Foundation provided financial support for the basic scientific studies that led to the clinical success of NYU Langone’s egg freezing and embryo bank program.

Source: NYU